The function and principle of red blood cell deformation meter

The function of the red blood cell deformation meter is to test the deformation ability of red blood cells. Red blood cell deformability refers to the ability of red blood cells to deform within blood vessels and pass through tiny blood vessels. If red blood cells have poor ability to deform within blood vessels, blood clots can occur.
The principle of the red blood cell deformation meter is: when red blood cells are subject to external physical stimulation, the relative displacement of internal water molecules and hemoglobin molecules will change, thereby changing the volume or shape inside and outside the cells. This process is called red blood cell deformation. The deformability of red blood cells is closely related to factors such as blood fluidity, oxygen dissociation capacity, tissue oxygen supply capacity, and pulmonary ventilation limitations that occur during exercise.

The principle of the red blood cell deformation meter is to use a special optical system in a fully automatic blood analyzer to cause dynamic changes in red blood cells during circulation and to continuously monitor their volume and shape. Specifically, it records and analyzes the number, volume, and morphological changes of red blood cells in the blood flow through a computer, and outputs the results in digital form.

Red blood cell deformability refers to the ability of red blood cells to deform when subjected to stress in the vasculature. This ability is critical to maintaining the lifespan of red blood cells and the normal function of blood circulation. The principle of the red blood cell deformation meter is to evaluate the ability of red blood cells to withstand stress by measuring their deformability.

Specifically, the red blood cell deformator uses a specific low-speed blood flow (usually 20-50 mm/min) to cause dynamic changes in red blood cells in the circulation. The instrument then uses a high-resolution optical system to take images of the red blood cells and continuously monitor their volume and morphology. The images are recorded and analyzed by a computer, and the output is represented in digital form.

Results are usually expressed as red blood cell aggregation index (CRI) or rolling index (Rolling Index). CRI is a common indicator for assessing the deformability of red blood cells, while rolling index is specifically used to measure the deformability of red blood cells. These indicators reflect the stress resistance of red blood cells and are important for understanding the pathophysiological processes of anemia and other blood diseases.